Columbia University Undergraduate Research Symposium 2020

Abstracts: https://www.college.columbia.edu/sites/default/files/final_-_2020_abstract_book_0.pdf

Faculty Mentor: Thomas Postler, Columbia University

Title: Uncovering the Role of lnc173 Mouse-Ortholog in T-Cell Biology

Abstract: T-cell activation is a crucial step in the adaptive immune response. Recent studies in T-cell lines have hinted at lnc173, a long non-coding RNA, as having a role in regulating cytokine production- signaling proteins that can either activate or suppress immune responses. Genomic analysis has been run for a wide range of publicly available RNA-seq data including both human and mouse T-cell data. Both lnc173 and its mouse ortholog are expressed to varying degrees within many T-cell datasets. Work is ongoing to integrate more datasets into this analysis and apply meta-analysis techniques to compare between-experiment results.

Poster & Video: https://my.undergrad.columbia.edu/s/ah-community-event/a1x1U000001BFhDQAW/theo-nelson