Khobrekar NV, Quintremil S, Dantas TJ, Vallee RB. The Dynein Adaptor RILP Controls Neuronal Autophagosome Biogenesis, Transport, and ClearanceDev Cell.


Gonçalves JC, Dantas TJ, Vallee RB. Distinct roles for dynein light intermediate chains in neurogenesis, migration, and terminal somal translocation. J Cell Biol. 218(3):808-819.


Wynne CL, Vallee RB. Cdk1 phosphorylation of the dynein adapter Nde1 controls cargo binding from G2 to anaphase. J Cell Biol. 217(9):3019-3029.

Zhou J, Scherer J, Yi J, Vallee RB. Role of kinesins in directed adenovirus transport and cytoplasmic exploration. PLoS Pathog. 14(5):e1007055.


Bertipaglia C, Gonçalves JC, Vallee RB. Nuclear migration in mammalian brain development. Semin Cell Dev Biol. 82:57-66.

Rosenfeld AB, Doobin DJ, Warren AL, Racaniello VR, Vallee RB. Replication of early and recent Zika virus isolates throughout mouse brain development. Proc Natl Acad Sci. 114(46):12273-12278

Doobin DJ, Dantas TJ, Vallee RB. Microcephaly as a cell cycle disease. Cell Cycle. (3):247-248.


*Doobin DJ, *Kemal S, *Dantas TJ, Vallee RB. Severe NDE1-mediated microcephaly results from neural progenitor cell cycle arrests at multiple specific stages. Nat Commun. 7:12551.

Reddy BJ, Mattson M, Wynne CL, Vadpey O, Durra A, Chapman D, Vallee RB, Gross SP. Load-induced enhancement of Dynein force production by LIS1-NudE in vivo and in vitro. Nat Commun. 7:12259

Dantas TJ, Carabalona A, Hu DJ, Vallee RB. Emerging Roles for Motor Proteins in Progenitor Cell Behavior and Neuronal Migration during Brain Development. Cytoskeleton (Hoboken).

Carabalona A, Hu DJ, Vallee RB.KIF1A inhibition immortalizes brain stem cells but blocks BDNF-mediated neuronal migrationNat Neurosci.19(2):253-62.

*Baffet AD, *Carabalona A, *Dantas TJ, *Doobin DD, *Hu DJ, *Vallee RB. Cellular and subcellular imaging of motor protein-based behavior in embryonic rat brain. Methods Cell Biol. 131:349-63

Yi J, Khobrekar NV, Dantas TJ, Zhou J, Vallee RB. Imaging of motor-dependent transport in neuronal and nonneuronal cells at high spatial and temporal resolution. Methods Cell Biol. 131:453-65


*Taylor SP, *Dantas TJ, Duran I, Wu S, Lachman RS; University of Washington Center for Mendelian Genomics Consortium, Nelson SF, Cohn DH, Vallee RB, Krakow D. Mutations in DYNC2LI1 disrupt cilia function and cause short rib polydactyly syndrome. Nat Commun.16;6:7092.

Scherer J, Vallee RB. Conformational changes in the adenovirus hexon subunit responsible for regulating cytoplasmic dynein recruitment. J Virol. 89(2):1013-23

Baffet, A.D., Hu, D.J, Vallee, R.B. Cdk1 Activates Pre-mitotic Nuclear Envelope Dynein Recruitment and Apical Nuclear Migration in Neural Stem Cells. Dev Cell 22;33(6):703-16

*Nicholas MP, *Höök P, Brenner S, Wynne CL, +Vallee RB, +Gennerich A.  Control of cytoplasmic dynein force production and processivity by its C-terminal domain. Nat Commun. 6:6206.


Scherer J, Yi J, Vallee RB. PKA-dependent dynein switching from lysosomes to adenovirus: a novel form of host-virus competition. J Cell Biol. 205(2):163-77

*Tripathy SK, *Weil SJ, Chen C, Anand P, +Vallee RB, +Gross SP. Autoregulatory mechanism for dynactin control of processive and diffusive dynein transport. Nat Cell Biol. 16(12):1192-201


*Hu, D.J., *Baffet A.D, *Nayak T, Akhmanova A., Doye V., Vallee R.B. Dynein recruitment to nuclear pores activates apical nuclear migration and mitotic entry in brain progenitor cells. Cell, Sep 12;154(6)


Hook, P., and Vallee, R. B. Dynein Dynamics. Nature Struct. Mol. Biol. 19:467-469.

Vallee, R. B., McKenney, R. J., and Ori-McKenney, K. M. Multiple modes of cytoplasmic dynein regulation. Nature Cell Biol. 14:224-230.

Harms, M., Ori-McKenney, K. M.,, Tuck, E. P., Bell, S., Ma, D., Masi, S., Allred, P., Reilly, P., Scoto, M., Muntoni, F., Miller, L. J., Shy, M. E., Pestronk, A., Vallee, R. B., and Baloh, R. H. Mutations in the tail domain of DYNC1H1 cause dominant spinal muscular atrophy. Neurology, 78:1714-1720.


Scherer J, Vallee RB. Adenovirus recruits dynein by an evolutionary novel mechanism involving direct binding to pH-primed hexon. Viruses. 3(8):1417-31

McKenney R. J., Weil, S. J., Scherer, J. and Vallee, R. B.Mutually exclusive cytoplasmic dynein regulation by NudE-Lis1 and dynactin. J. Biol. Chem. 286:39615-39622.

Yi, J, Ori-McKenney, K. M., McKenney, R. J., Vershinin, M., Gross, S. P., and Vallee, R. B. (2011).High-resolution imaging reveals indirect coordination of opposite motors and a role for LIS1 in high-load axonal transport. J. Cell Biol. 195:193-201.

*Cappello, S., *Monzo, P, and Vallee, R. B. NudC is required for interkinetic nuclear migration and neuronal migration during neocortical development. Dev. Biol. 357:326-335.

Ori-McKenney, K. M. and Vallee, R. B. Neuronal migration defects in the Loa dynein mutant mouse. Neural Dev. 6:26.

Bolhy S, Bouhlel I, Dultz E, Nayak T, Zuccolo M, Gatti X, Vallee R, Ellenberg J, Doye V. A Nup133-dependent NPC-anchored network tethers centrosomes to the nuclear envelope in prophase J. Cell Biol. 192:855-71.

Tan SC, Scherer J, Vallee RB. Recruitment of dynein to late endosomes and lysosomes through light intermediate chains. Mol Biol Cell. 22(4):467-77


*Tsai, J.-T., *Lian, W.-N., Kemal, S., Kriegstein, A., and Vallee, R. B.Kinesin 3 and cytoplasmic dynein mediate interkinetic nuclear migration in neural stem cells. Nature Neurosci. 13:1463-1471.

*Ori-McKenney, K. M., *Xu, J., +Gross, S. P., and +Vallee, R. B.A cytoplasmic dynein tail mutation impairs motor processivity. Nature Cell Biol. 12:1228-1234.

*McKenney, R. J., *Vershinin, M., +Vallee R. B., and +Gross, S. P.LIS1 and NudE induce a persistent dynein force-producing state. Cell 141:304-314

Varma, D. Dawn, A., Ghosh Roy, A., Zhao, Y, Keen, J., Vallee, R. B., and Williams, J. C.Development and application of in vivo molecular traps reveals that dynein light chain occupancy differentially affects dynein-mediated processes. Proc. Natl. Acad. Sci. USA. 107: 3493-3498


Bremner, K. H., Scherer, J., Yi, J., Vershinin, M., Gross, S. P., and Vallee, R. B.Adenovirus transport via direct interaction of cytoplasmic dynein with the viral capsid hexon subunit. Cell Host Microbe 6:523-535.

Wang, X., Tsai, J.-W., Lian, W.-L., Vallee, R. B., and Shi, S.-H.Asymmetric centrosome inheritance maintains neural progenitors in the neocortex. Nature 461:947-955.

Vallee, R. B., Seale, G. E., and Tsai, J.-W.Emerging roles for myosin II and cytoplasmic dynein in migrating neurons and growth cones. Trends Cell Biol.19:347-355

Höök P, Yagi T, Ghosh-Roy A, Williams JC, Vallee RB. The dynein stalk contains an antiparallel coiled coil with region-specific stability. Biochemistry. 48(12):2710-3


Varma, D., Stehman, S. A., Monzo, P., and Vallee, R. B.Direct role of dynein motor in stable kinetochore-microtubule attachment, orientation, and alignment. J. Cell Biol. 182:1045-1054.


Suzuki SO, McKenney RJ, Mawatari SY, Mizuguchi M, Mikami A, Iwaki T, Goldman JE, Canoll P, Vallee RB. Expression patterns of LIS1, dynein and their interaction partners dynactin, NudE, NudEL and NudC in human gliomas suggest roles in invasion and proliferation. Acta Neuropathol. 113(5):591-9

Stehman, S. A., Chen, Y., McKenney, R. J., and Vallee, R.B.NudE and NudEL are required for mitotic progression and are involved in dynein recruitment to kinetochores. J. Cell Biol, 178:583-594

Tsai, J.W., Bremner, K.H. , and Vallee, R.B.Dual subcellular roles for LIS1 and dynein in radial neuronal migration in live brain tissue. Nat Neurosci. 10:970-9.

Grabham, P.W., Seale, G.E. , Bennecib, M., Goldberg, D.J. and Vallee, R.B..Cytoplasmic dynein and LIS1 are required for microtubule advance during growth cone remodeling and fast axonal outgrowth. J Neurosci. 27:5823-34.


Vallee RB, Höök P. Autoinhibitory and other autoregulatory elements within the dynein motor domain. J Struct Biol. 156(1):175-81

Vallee RB, Tsai JW. The cellular roles of the lissencephaly gene LIS1, and what they tell us about brain development. Genes Dev. 20(11):1384-93

Vallee RB, Varma D, Dujardin DL. ZW10 function in mitotic checkpoint control, dynein targeting and membrane trafficking: is dynein the unifying theme? Cell Cycle. 5(21):2447-51

Varma, D.*, Dujardin, D. L.*, Stehman, S. A., and Vallee, R. B.Role of the kinetochore/cell cycle checkpoint protein ZW10 in interphase cytoplasmic dynein function. J. Cell Biol. 172:655-672

Höök P, Vallee RB. The dynein family at a glance. J Cell Sci. 119(Pt 21):4369-71


Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB. Cytoplasmic dynein nomenclature. J Cell Biol. 171(3):411-3

Tsai, J. W.; Chen, Y.; Kriegstein, A. R.; Vallee, R. B.LIS1 RNA interference blocks neural stem cell division, morphogenesis, and motility at multiple stages. J. Cell Biol. 170:935-45.

Reubold TF, Eschenburg S, Becker A, Leonard M, Schmid SL, Vallee RB, Kull FJ, Manstein DJ. Crystal structure of the GTPase domain of rat dynamin 1. Proc Natl Acad Sci U S A.102(37)

Höök P, Mikami A, Shafer B, Chait BT, Rosenfeld SS, Vallee RB. Long range allosteric control of cytoplasmic dynein ATPase activity by the stalk and C-terminal domains. J Biol Chem. 280(38):33045-54.

Vallee RB, Stehman SA. How dynein helps the cell find its center: a servomechanical model. Trends Cell Biol.15(6):288-94.

Vallee RB, Williams JC, Varma D, Barnhart LE. Dynein: An ancient motor protein involved in multiple modes of transport. J Neurobiol. 58(2):189-200. Review.


Dujardin DL, Barnhart LE, Stehman SA, Gomes ER, Gundersen GG, Vallee RB. A role for cytoplasmic dynein and LIS1 in directed cell movement.163(6):1205-11.

Vallee RB, Höök P. Molecular motors: A magnificent machine. Nature. 421(6924):701-2. No abstract available.


Mikami A, Tynan SH, Hama T, Luby-Phelps K, Saito T, Crandall JE, Besharse JC, Vallee RB. Molecular structure of cytoplasmic dynein 2 and its distribution in neuronal and ciliated cells. J Cell Sci. 115(Pt 24):4801-8.

Tai CY, Dujardin DL, Faulkner NE, Vallee RB. Role of dynein, dynactin, and CLIP-170 interactions in LIS1 kinetochore function.J Cell Biol. 156(6):959-68.
Dujardin DL, Vallee RBDynein at the cortex. Curr Opin Cell Biol. 14(1):44-9. Review.


Okamoto PM, Gamby C, Wells D, Fallon J, Vallee RB. Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton.J Biol Chem. 276(51):48458-65.

Vallee RB, Tai C, Faulkner NE. LIS1: cellular function of a disease-causing gene.Trends Cell Biol. 11(4):155-60. Review.


Faulkner NE, Dujardin DL, Tai CY, Vaughan KT, O’Connell CB, Wang Y,Vallee RB. A role for the lissencephaly gene LIS1 in mitosis and cytoplasmic dynein function.Nat Cell Biol. 2(11):784-91.

Tynan SH, Gee MA, Vallee RBDistinct but overlapping sites within the cytoplasmic dynein heavy chain for dimerization and for intermediate chain and light intermediate chain binding. J Biol Chem. 275(42):32769-74.

Tynan SH, Purohit A, Doxsey SJ, Vallee RB. Light intermediate chain 1 defines a functional subfraction of cytoplasmic dynein which binds to pericentrin. J Biol Chem. 275(42):32763-8.

Vallee RB, Faulkner NE, Tai CY. The role of cytoplasmic dynein in the human brain developmental disease lissencephaly. Biochim Biophys Acta. 1496(1):89-98. Review.

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