Below are examples of a few ways to use the Health Sciences Library’s (HSL) Resources to find the answers to these questions.

1. What is the pathophysiology of hemophilia A?

  • This is a background or general question which can be answered by consulting a textbook.  For information on the pathophysiology (or physiopathology) of hemophilia A, search e-books from Access Medicine. From the HSL homepage http://library.cumc.columbia.edu/  select>Top Resources> Access Medicine; in the search box type Hemophilia A  Pathophysiology; the results (for example) include Williams’ Hematology. Scroll to find a chapter on: Classic Hemophilia, Factor VIII Deficiency. A similar search can be conducted in StatRef, which is another e-book resource. From the HSL homepage select >Top Resources>StatRef.
  • A search in the MeSH database (within PubMed) for hemophilia a can also be done, select the subheading physiopathology from the list of subheadings. Add the selection to the ‘Add to search builder’ on right of page and then select ‘Search PubMed’.  This will launch a search in PubMed, based on your selections.

2. Are there any books that provide an overview on dental care for medically compromised patients?

  • A search can be done in CLIO (Columbia’s Library Catalog).

3. What is the recommended management of patients with hemophilia A undergoing oral surgery?

  • From the HSL homepage http://library.cumc.columbia.edu/  select>Top Resources> PubMed
    • Search strategy suggestion: Hemophilia A AND oral surgery
      • Below are a few selected citations
      • Antifibrinolytic therapy for preventing oral bleeding in patients with haemophilia or Von Willebrand disease undergoing minor oral surgery or dental extractions. van Galen KP, Engelen ET, Mauser-Bunschoten EP, van Es RJ, Schutgens RE. Cochrane Database Syst Rev. 2015 Dec 24;(12):CD011385. doi: 10.1002/14651858.CD011385.pub2.  PMID: 26704192
      • Oral surgery-associated postoperative bleeding in haemophilia patients – a tertiary centre’s two decade experience.  Givol N, Hirschhorn A, Lubetsky A, Bashari D, Kenet G. Haemophilia. 2015 Mar;21(2):234-40. doi: 10.1111/hae.12573. Epub 2014 Dec 4.  PMID: 25470999
  • Another search option is to only search for Hemophilia A and then limit your retrieval to Dental Journals by selecting the filters on the left pane in your PubMed search; or you may opt to type this in the search box as follows:  hemophilia a AND jsubsetd;  (Note: jsubsetd stands for Journal Subset Dental; Use this limit with caution, as you will greatly reduce your results).
    • Some citations retrieved are as follows:
      • Congenital bleeding disorders and dental surgery.  Spivakovsky S, Keenan AV, Congiusta M, Spivakovsky Y.  Evid Based Dent. 2015 Sep;16(3):90-1. doi: 10.1038/sj.ebd.6401121. No abstract available.  PMID: 26492808
      • Hemophilia and oral health.  Zaliuniene R, Peciuliene V, Brukiene V, Aleksejuniene J.  Stomatologija. 2014;16(4):127-31. Review.  PMID: 25896036
      • Management of dental extraction in patients with Haemophilia A and B: a report of 58 extractions.  Peisker A, Raschke GF, Schultze-Mosgau S.  Med Oral Patol Oral Cir Bucal. 2014 Jan 1;19(1):e55-60.  PMID: 24121912
  • A search can also be done in Embase; select Embase from the HSL homepage http://library.cumc.columbia.edu/  select>Top Resources>Embase; Search strategy suggestion: ‘Dental Procedure’/exp AND ‘Hemophilia A’/exp
    • Some citations are as follows:
      • Combined factor V and VIII deficiency in a young woman with abundant bleeding after tooth extraction. Ates I., Kaplan M., Tokgoz G., Ceran F., Akalin S., Ozet G. Blood Research 2016 51:1 (67-68)
      • Factors influencing risk of bleeding after dental extraction in hemophilia patients. Miljić P., Bodroźić J., Elezović I., Juris̈ić M., Brković B., Antić D., Leković D., Mitrovic M. Journal of Thrombosis and Haemostasis 2015 13 SUPPL. 2 (586-587)

4. What are the practice guidelines for treating patients with hemophilia?

Search strategy suggestion: PubMed: Hemophilia A [Mesh] AND Practice Guideline [ptyp]Note: [Mesh] refers to Medical Subject Headings; [ptyp] refers to publication type.

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